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Augmentin 325 price was increased to $22,625 and $22,919 match its predecessor. As a result, the total price to purchasers of Aequorin 325 for a 21,000-mg dose was now $22,625 or $29.50 per pill. The price reduction in December 2008 was achieved through several steps: a new formulation was prepared, second-generation containing the full active ingredient was developed for FDA approval and a new product label was published and introduced that included the new price. second-generation formulation and label the new together were introduced in February 2009 and were approved by the FDA on July 29, 2009 (PATRICIA). A more recent report from GSK on December 17, 2009, also reported that it had launched a new Aequorin 325 formulation that, according to the report, is "100% pure": Aqorin 325 is formulated under a new trademark (Aeqorin) with stronger formula for maximum bioavailability. It is available via a single-dose dispensing device for 21,000-mg dose. This is the same formulation offered by GSK to patients in the United States under its Aequorin brand, and the same formulation as Aeqorin 325 that was available in Australia 2010 (PATRICIA 2009). In this report, GSK states that it developed the new formulation using a novel approach, as discussed later in this section. The FDA first approved Aequorin 325 in 2002 (PATRICIA 2008). Divalproex sodium (Duloxetine Hydrochloride) Divalproex sodium is a major antidepressant and was first approved in 1998 for the treatment of depression in patients 6 years or older. It is indicated for the treatment of depressive disorder that is not adequately treated by psychotherapy. A higher dose of 20 mg once daily was introduced in 1998 and is also an extended-release version of Divalproex sodium. Its major manufacturer is Schering-Plough. The price for a 30-day course of treatment with Divalproex sodium ranged from $4,000 to $8,500 depending on the site of prescription. At time AORI was released (2003), the lowest price available from any source was $7,400. In February 2011, a report on an FDA-approved study of the new formulation 20% Aqorin 325 and Divalproex sodium was published (JOURNAL OF AMERICAN MEDICINE 2010). AQORIN 325 was shown to be as effective Dival proex sodium for the major depressive episode (MDE) for which it was designed, but more so for its secondary depression (DEP) and the treatment of mild-to-moderate dysthymia (GALLUP BOLTER INDEX 2011). In February 2009, a follow-up report on the same study was published (JOURNAL OF AMERICAN MEDICINE 2009). The manufacturer discontinued Divalproex sodium in December 2009, following the release of study results (JOURNAL AMERICAN MEDICINE 2009). Effexor XR (Elavil) Effexor XR (Elavil) is another major and widely licensed antidepressants. Elavil was approved by the FDA augmentin medicine price in 1997 and it is marketed by Bristol-Myers Squibb as Effexor.

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